Enantioselective Assembly of Spirolactones through NHC-Catalyzed Remote γ-Carbon Addition of Enals with Isatins.
نویسندگان
چکیده
A chiral N-heterocyclic carbene (NHC)-catalyzed formal [4 + 2] annulation of β-methyl substituted enals with isatins was developed to construct six-membered spirolactones bearing highly congested quaternary carbon stereocentersin good yields and high enantioselectivities. The strategy realized a challenging remote γ-carbon addition of enals and chiral control of β-methyl substituted enals in the presence of the NHC catalyst only.
منابع مشابه
Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins.
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Chem. Commun., 2015, 51, 8385 | 8385 Cite this:Chem. Commun., 2015, 51, 8385 Correction: A new chiral C1-symmetric NHC-catalyzed addition to a-aryl substituted a,b-disubstituted enals: enantioselective synthesis of fully functionalized dihydropyranones Hong Lu, Jin-Yu Liu, Chen-Guang Li, Jun-Bing Lin, Yong-Min Liang and Peng-Fei Xu* Correction for ‘A new chiral C1-symmetric NHC-catalyzed additi...
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عنوان ژورنال:
- ACS combinatorial science
دوره 18 5 شماره
صفحات -
تاریخ انتشار 2016